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Crucial things you need to learn before planning liver function tests
Liver
Thu Dec 07 2023
Before planning liver function tests, it is highly imperative to have a basic understanding of the liver and its physiology. Here are a few crucial things to learn:
1. Liver anatomy and function: Understand the basic structure and function of the liver. The liver is the largest internal organ responsible for many vital functions, including detoxification, metabolism, bile production, and storage of essential nutrients.
2. Liver diseases: Familiarize yourself with common liver diseases such as hepatitis (viral, alcoholic, autoimmune), cirrhosis, fatty liver disease, liver tumours, and drug-induced liver injury. Understanding the pathophysiology and clinical features of these conditions is important when evaluating liver function.
3. Liver function tests (LFTs): Learn about different liver function tests and their interpretation. Common LFTs include alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, albumin, and prothrombin time. Understand the significance of these tests in assessing liver function and diagnosing liver diseases.
4. Normal reference ranges and patterns: Familiarize yourself with the normal reference ranges for different liver function tests and the patterns observed in different liver diseases. Abnormal liver function test results can provide important clues about the underlying liver pathology.
5. Interpreting liver function test results: Understand the significance of elevated or decreased levels of liver function tests. While some tests specifically reflect liver damage (e.g., ALT, AST), others indicate impaired synthetic or excretory functions (e.g., albumin, bilirubin). Interpreting results in combination with clinical history, physical examination, and other diagnostic tests is crucial.
6. Differential diagnosis: Recognize that abnormal liver function tests can occur due to various reasons, including liver diseases, medications, infections, metabolic disorders, and systemic conditions. Understanding the differential diagnosis based on liver function test abnormalities helps guide further investigations and management.
7. Additional diagnostic tests: Learn about additional diagnostic tests that can help assess liver function and determine the cause of liver disease, such as viral serologies (e.g., Hepatitis B, C), imaging studies (e.g., ultrasound, CT scan), liver biopsy, and specialized tests (e.g., FibroScan for liver fibrosis assessment).
Remember, interpreting liver function tests requires a comprehensive approach, including clinical judgment, integration of patient history, physical examination findings, and other relevant investigations. It is important to consult with a healthcare professional or a hepatologist for a comprehensive evaluation and management plan based on the specific clinical scenario.
Manipal TRUtest offers a wide range of diagnostic services with assured quality, accuracy, and trust backed by 70 years of Manipal legacy. You can easily schedule a blood test through our WhatsApp Chatbot, Mobile App, or Website. We also provide the convenience of a Home Sample Collection, where a highly qualified phlebotomist will visit you in the comfort of your home.
Also Read: Kidney Stones EXPOSED: The causes, symptoms, treatment and prevention
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Liver
Revolutionary Non-Invasive Screening Tool for Liver Diseases Launched
An non-invasive screening tool for liver diseases has been launched and it is set to transform how these conditions are diagnosed. This innovative technology aims to detect liver diseases early, eliminating the need for uncomfortable and risky invasive procedures like biopsies.
Introducing the New Screening Tool
The newly launched tool uses advanced imaging techniques to evaluate liver health. It utilizes elastography, a method that measures the stiffness of liver tissue. When the liver is damaged or diseased, it often becomes stiffer. By assessing this stiffness, healthcare providers can identify potential issues such as fatty liver disease, fibrosis, and cirrhosis without the need for a tissue sample.
Why This Tool Matters
Liver diseases are a major health concern worldwide. Conditions like fatty liver disease, hepatitis, and cirrhosis can lead to serious complications if not detected early. Traditional diagnostic methods often involve invasive procedures that can be painful and require recovery time. The new screening tool presents a safer and more comfortable alternative for patients.
How the Screening Process Works
The screening process is simple and quick. Patients lie down while a small device is placed on their abdomen. This device sends sound waves into the liver to measure its stiffness. Results are usually available within minutes, allowing doctors to make timely decisions about any further testing or treatment needed.
Who Should Consider Getting Tested?
This screening tool is especially beneficial for individuals at higher risk of liver diseases, including:
- Individuals with obesity: Excess weight can lead to fatty liver disease.
- People with diabetes: Diabetes increases the risk of liver problems.
- Heavy drinkers: Prolonged alcohol consumption can damage the liver over time.
- Those with a family history of liver disease: Genetics can play a role in susceptibility to liver conditions.
If you fall into any of these categories or experience symptoms such as fatigue, abdominal pain, or jaundice (yellowing of the skin and eyes), it is advisable to discuss screening options with your healthcare provider.
Additional Testing Options
While the non-invasive screening tool is effective for initial assessments, further tests may be required if abnormalities are detected. Common follow-up tests include:
- Blood tests: To evaluate liver function and related markers.
- Imaging studies: Such as ultrasound or CT scans for detailed views of the liver.
- Liver biopsy: In certain cases, a biopsy may still be recommended to confirm a diagnosis.
Conclusion
The introduction of this non-invasive screening tool represents a significant advancement in the detection and management of liver diseases. This innovative approach not only enhances patient comfort but also encourages more individuals to get screened regularly, ultimately leading to better health outcomes in managing liver diseases.
Liver
The Liver's Lament: A Light Hearted Yet Sobering Tale on World Liver Day
In the grand tapestry of human health, few organs have as much character as the liver. Sitting quietly in the abdomen, this unsung hero has a knack for resilience that rivals even the most battle-hardened superheroes. But alas, even the mightiest warrior has its kryptonite, and for our dear liver, it's the nefarious villains of alcohol, unhealthy lifestyle and other substances.
Welcome, dear readers, to the wacky world of the liver, where drama unfolds faster than you can say "teetotaller." Today, as we commemorate World Liver Day, let us embark on a journey filled with laughter, tears, and perhaps a touch of jaundice.
Wreaking havoc faster than you can say "last call", is our first contender, the good old liquid elixir of gods, Alcohol. Like an unruly guest who overstays their welcome, alcohol causes multiple effects on the liver by over stressing it leading to inflammation, scarring (Fancy word Cirrhosis) and even Liver Failure.
But wait, there's more! Alcohol isn't the only troublemaker in town. Illicit substances, like the troublemakers cocaine to heroin to methamphetamine, these substances have been known to cause a myriad of liver issues, from fatty liver disease to hepatitis to—you guessed it—cirrhosis.
Now, before you start barricading your liquor cabinets and installing security cameras, let's take a moment to appreciate the liver's resilience as well. Despite its fair share of abuse, the liver soldiers on, like a valiant knight in tarnished Armor. Just like wolverine, it has a remarkable ability to regenerate, akin to a phoenix rising from the ashes (or in this case, from a night of heavy drinking). With the right care and a bit of TLC, the liver can bounce back faster than you can imagine.
When it comes to numbers on a serious note, liver diseases encompass a broad spectrum of conditions, ranging from viral hepatitis and fatty liver disease to cirrhosis and liver cancer. According to the World Health Organization (WHO), liver diseases account for approximately 2 million deaths annually, making it a leading cause of mortality worldwide. But these figures only scratch the surface of the global liver health crisis.
Viral hepatitis, notably hepatitis B and hepatitis C, stands as a formidable adversary in the fight against liver diseases. The WHO estimates that over 325 million people are living with chronic hepatitis B or hepatitis C infection, with a staggering 1.34 million deaths attributed to viral hepatitis each year. These statistics underscore the urgent need for widespread vaccination, screening, and access to affordable treatment options to curb the spread of these silent killers.
The infamous, Fatty Liver disease, once considered a consequence of excessive alcohol consumption, has emerged as a growing concern in tandem with the obesity epidemic. Non-alcoholic fatty liver disease (NAFLD) affects approximately 25% of the global population, with prevalence rates soaring in tandem with rising obesity rates. Alarmingly, NAFLD has become a leading cause of liver-related morbidity and mortality, highlighting the critical importance of lifestyle modifications and early intervention strategies.
Furthermore, policies aimed at reducing alcohol consumption, promoting healthy lifestyles, and tackling obesity are integral to mitigating the risk factors associated with liver diseases. Investment in healthcare infrastructure, particularly in resource-constrained settings, is essential to ensuring equitable access to essential services, including diagnostic tests, medications, and specialized care for individuals living with liver diseases.
Liver cancer, a devastating consequence of untreated liver diseases, ranks as the fourth most common cause of cancer-related deaths worldwide. Annually, over 830,000 new cases of liver cancer are diagnosed, with mortality rates continuing to climb despite advances in treatment modalities. Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, disproportionately affects regions with high rates of viral hepatitis and limited access to healthcare resources, underscoring the critical importance of early detection and intervention programs.
The burden of liver diseases extends beyond mortality rates, encompassing a myriad of socioeconomic and healthcare challenges. In low- and middle-income countries, limited access to essential healthcare services, including vaccination programs, diagnostic tools, and life-saving treatments, exacerbates the impact of liver diseases, perpetuating a cycle of poverty and inequity. Moreover, stigma and misconceptions surrounding liver diseases often deter individuals from seeking timely medical care, resulting in delayed diagnoses and poorer health outcomes.
Addressing the global liver health crisis requires a multi-faceted approach, encompassing preventive measures, early detection strategies, and equitable access to treatment and care. Public health initiatives, including vaccination campaigns targeting hepatitis B and hepatitis C, play a pivotal role in reducing disease burden and preventing transmission. Screening programs, coupled with increased awareness and education efforts, empower individuals to take proactive steps towards liver health and well-being.
Let us unite in solidarity to raise awareness, advocate for change, and stand in solidarity with those affected by liver diseases. Let us raise a toast (alcohol-free, of course) to the unsung hero of our bodies—the liver. Through thick and thin, through booze and bruises, it continues to soldier on, reminding us that even in the darkest of times, there's always hope for a brighter, healthier tomorrow.
This World Liver Day, let's make a pledge to treat our livers with the respect they deserve. Whether it's cutting back on the alcohol & nefarious substances, embracing a healthier lifestyle, or simply saying "thank you" for all the hard work, let's show our livers some love.
And remember, folks: when life gives you lemons, make lemon water. Your liver will thank you for it. Cheers to good health!
Liver
How Much CRP Level is Dangerous?
CRP stands for C-reactive protein, which is a protein produced by the liver in response to inflammation in the body. It is commonly used as a marker to assess levels of inflammation. Are you curious to find out the necessary information about C-reactive protein test? This is the place to be:
CRP LEVEL RANGES:
The normal range of CRP in healthy adults is typically less than 10 milligrams per liter (mg/L). However, CRP levels can vary depending on the testing method used by different laboratories.
CRP levels above 10 mg/L are considered elevated and may indicate inflammation caused by various conditions, such as infections, inflammatory disorders, or tissue injury. Higher CRP levels, such as those above 100 mg/L, are generally considered to indicate more severe inflammation.
How Much CRP Level is Dangerous?
CRP levels alone are not necessarily dangerous, but higher levels can be a sign of underlying health issues that should be investigated and treated. It's important to consult with a healthcare provider for proper evaluation and interpretation of CRP levels in the context of your overall health.
Symptoms of CRP Levels:
Here are some common symptoms related to CRP:
1. General Signs of Inflammation: Increased levels of CRP often accompany symptoms such as redness, swelling, warmth, and pain at the site of inflammation.
2. Fever: Fever is a common sign of inflammation, and elevated CRP levels may be present in conditions where fever is a prominent symptom.
3. Fatigue: Feeling tired and lacking energy is a common symptom associated with inflammatory conditions. Elevated CRP levels can be linked to fatigue.
4. Loss of Appetite: Inflammatory conditions can affect your appetite, leading to a decreased desire to eat. If CRP levels are high, you may experience a loss of appetite.
5. Muscle and Joint Pain: Inflammation can cause pain in the muscles and joints. Elevated CRP levels can be found in conditions like arthritis, where joint pain is a significant symptom.
6. Malaise: General feelings of unease, discomfort, or illness without a specific cause are often reported in conditions with elevated CRP levels.
It's important to note that elevated CRP levels are a marker of inflammation, not a specific disease. The symptoms associated with CRP elevation can vary depending on the underlying cause of inflammation. If you suspect high CRP levels based on symptoms, it's essential to consult a healthcare practitioner before going for a diagnostic test.
Manipal TRUtest offers a wide range of diagnostic services with assured quality, accuracy, and trust backed by 70 years of Manipal legacy. You can easily schedule a blood test such as Diabetes profile test, HbA1c, CBC, Kidney Function Test, Lipid Profile, Liver Function Test, Vitamin Test. Thyroid Profile. through our WhatsApp Chatbot, Mobile App, or Website. We also provide the convenience of a Home Sample Collection, where a highly qualified phlebotomist will visit you in the comfort of your home.
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Reference Links:
https://www.relainstitute.com/blog/how-much-crp-level-is-dangerous/#:~:text=CRP%20levels%20can%20vary%20widely,mg%2FL%20indicate%20severe%20inflammation.
https://my.clevelandclinic.org/health/diagnostics/23056-c-reactive-protein-crp-test
https://www.drkarunhematology.com/blog/how-much-crp-level-in-the-blood-is-considered-dangerous/